Gulf War Illness Explained in the Simplest Terms
Gulf War Illness Explained in the Simplest Terms
By: Jim Phelps
Copyright 2005
The 1991 Persian Gulf War still affects hundreds of thousands of American Veterans from the "toxic soup" that cut some 30 years off many of their life-spans. There has been much discussion of the toxic soup's components that have taken the terrible toll on those exposed. The significant toxic exposures were aluminum and mercury in vaccines, the Depleted Uranium from munitions, the oil well fires, the nerve gases that hydrolyses to hydrogen fluoride, DEET, PB, high chlorine in drinking water, methanol from "Nutrasweet" soft drinks, and other insecticides.
All these varied toxic materials leave many people mystified as to what are the main components driving the long term illnesses showing up in many of the hundreds of thousands of people sent into the Gulf War zone and others that never entered the war zone who also became sick from only the vaccines. The question becomes what is the common factor that connects all these persons leading to this similar illness pattern. There were some immediate effects due to consumption of high amounts of Nutrasweet beverages in the hot climates that put many soldiers well over the safe levels of methanol, which began some of the nervous system damage. This was made worse by damage to repair enzymes like SOD, due to varied chemical exposures that lowered this essential enzyme.
The common factor that connects to all the illness is not a mystery and is a well known effect, but one that is suppressed. The common mechanism is the loss of enzymes in the human body and the main two involved are glurathione (GSH) and SuperOxide Dimutase (SOD). Glutathione is the main enzyme that clears many toxic metals from the body and without it being at full potential toxic metals concentrations rise in the body leading to increases in free radical damage to cells via reactive oxygen damage (ROS). SOD is responsible for repair of the ROS damage to the cells. So, the main problem is both the loss of the mechanism that clears the toxic material and the loss of the mechanism that repairs the damage due to rise in the toxic materials driving high rates of ROS damage.
The other key enzyme is one called RNase L which is damaged by the high free radical effects from the toxic metals interaction with cell mitochondria. The RNase L enzyme is the key one that controls viral infections (and also mycoplasma, bacteria) within cells. High radiation generation of free radicals also damages this same enzyme class and results in viral infections that are typically controlled with these enzymes. Inner cell infections like mycoplasmas can appear that require antibiotics to control.
GSH and SOD also care for the brain and pass easily into the brain tissues. The GSH clears the brain of toxic metals, like mercury and lead, and the SOD tries to heal the damage caused by the toxic metals substituting into cell processes that lead to ROS damage. The "brain fog" or "foggy thinking" that associates with Gulf War Illness is a direct result of lowered levels of GSH and SOD in the body and is a first order sign for this type mechanism being of prime importance.
The prime causes of reduced GSH and SOD are toxic materials like HF (hydrogen fluoride), AlFx, DEET, mercury, PCB, chlorine, insecticides, and a lack of vegetables and fruits in diets. Everyone in the US today has some degree of GSH and SOD suppression and the problem worsens with age. Many of these toxic materials highly retain in the body and the leading problems come from mercury, PCBs, and fluorides. The mercury component and the bad diets lead many vets to get many of the Gulf War Illness symptoms just due to the many killed vaccines they received that employed mercury.
The reduction of the clearance of toxic metals due to GSH is easily observed in the population as it plays a direct role in why hair turns gray. Grey hair is caused principally by rising levels of Hg or mercury in the body being incorporated into the hair follicles causing the loss of pigment from the higher cellular ROS problems. Grey hair has higher levels of mercury in it than pigmented hair strands and the effect helps to pull some mercury from tissues. Grey hair for many people begins in areas of the chin and face, where the highest concentrations of mercury tend to accumulate in tissues from mercury dental fillings. With increasing age the gray hair can affect most of the head's hair. This is a common example of the effects of reduced GSH and SOD enzymes that happens with age and rise of internal retention of PCB, pesticides, HF, and Hg that act to damage GSH and SOD production.
The enzyme GSH removes toxic metals from the brain and tissues by combining the toxic metals with sulfur and then an excretion pathway via the bile into the feces and out of the body. As GSH levels in the body fall from chemical poisoning effects it places more of a load on the kidney pathway of excretion. The toxic metals loading on the kidney can become too large easily and damage the renal tubule cells leading to less excretion rate and an acid shift of the blood that enhances the toxic metals retention problems. The failure of the GSH pathway to remove metals from the body and the damage of the kidney pathway to remove metals from the body produces a rise in toxic metal retention in the body, high ROS levels, and very high risk for cancer and all the immune linked illnesses. The failure of the kidney pathway to remove toxic metals generally shows with porphyria in the urine.
Vets that came to the war zone were exposed to HF from nerve gas demolition plumes of hydrogen fluoride enzyme system poisons drifting into their breathing air space that damaged the GSH and SOD levels. Vets were also exposed to DEET, oil hydrocarbons, and insecticide sprays the also damaged GSH and SOD levels. The net result of this long term poisoning effect is a slow rise in the toxic metals (Hg, Pb, Al, Cd, etc.) concentrations in the body and a slow decline of the beneficial trace metals (Zn, Mg, Se, Cu, etc.) in the body that support the formation of GSH and SOD. One can even look at the recovery regimen that GWI researcher named Dr. Garth Nicholson recommends and find he recommends minerals and other factors that boost these beneficial trace elements and GSH and SOD. Nicholson was the first to spot mycoplasma effects in GWI, and the mycoplasma problems are also common to radiation exposures due to high levels of ROS damage to RNase L cellular enzymes in the body generated by high radiation.
This basic mechanism for illness is common to the Chronic Fatigue Syndrome (CFS) and the illnesses of the DOE gas diffusion plant workers. The most damage to the GSH and SOD in these cases is due to the rise of fluoride and HF exposures that lead to the upset of the metals metabolism in the body. The health damage is due to high levels of ROS that lead to health problems that look like they are caused by internal radiation free radical damage. The rise of the toxic metals and the acid pH shifts in the blood lead to kidney cell damage that has the appearance of DU type heavy metals poisoning. When the body's pH goes into the acid domain the metals retention is high and the ROS damage to cells extreme and usually results in cancer virus activation.
In areas like Oak Ridge where high levels of chemicals like HF kill off the GSH and SOD enzyme clearance of mercury from the body one finds higher rates of thyroid damage. High levels of mercury are well associated with hypothyroidism and Hashimoto's Thyroiditis. Sometimes the thyroid effects in Oak Ridge have the appearance of hyperthyroidism when there is too much cadmium and the high free radical damage due to loss of SOD. It is a very similar effect that damages the kidneys that potentiates toxic metals retention.
The worst effect from GWI comes from the fluoride and aluminum vaccine effects that spontaneously form AlFx compounds that mimic the pituitary hormone TSH. The AlFx compound then determines the levels of thyorid gland and liver T-3 and T-4, which program the energy levels in the mitochondria of every cell in the body. It is this effect that results in the depletion of the GSH levels needed in all the cells of the body. This effect causes the night sweats that are common to both people with CFS and GWS. It also causes the loss of restful sleep and the inability to sleep because the cells won't power down like they would under the control of the pituitary gland.
It is this thyroid hormone mimic problem that lies at the very heart of GWI, because so little of a chemical can cause such a global effect on all cells in the body. The effect that is produced is like that of hyperthyroidism, which leaves people very tired, often sleepless, and will little cellular GSH. The standard thyroid test using TSH results in misdiagnosis of hypothyroidism because these persons will test low for TSH and be uncommonly tired. This effect leads to the confusion on GWS by many doctors and it also leads to ways to cover up the health problems by testing only for TSH. Only the Thyroid Panel tests begin to show the T-3 and T-4 high level problems that the AlFx compound causes in the GWI equation.
The key to the AlFx TSH hormone mimic effect is that AlFx compounds don't follow the night and day amplitude and pulse fluctuations of the normal pituitary TSH. The AlFx compounds have drastically different bonding characteristics to TSH receptor sites of cells due to the fact that highly electronegative fluorine is involved in the site bonding. This effect results in a nearly permanent bond to the receptor sites for TSH, which highly upsets the normal thyroid hormone regulation process. It is this effect that depletes the GSH in every cell in the body and why the Al and F contamination effects are often the worst on GSH levels and the illness processes.
The bottom line is that 10 days of war took 30 plus years off the lives of hundreds of thousands of US soldiers that entered this conflict. Hundreds of thousands of Vets were exposed to some of the most retained chemical poisons on the planet that killed their GSH and SOD levels leading to health problems about like those of a 60-year-old female. Some have brain injury so severe from the toxic metals effects on the brain that look like the seizures of Minimata Disease. Gone was their prime of life and health and 20-30 year old people were suddenly given the health of life outlook for an elderly person. If one considers the typical life span these days as being 75 years, then the loss of 30 years from the life span of each of the 800,000 people in the Gulf War means 400,000 people effectively died from this toxic soup war zone.
The American Government appears interested in offering up DU as the principle reason for all the rise of cancers in Iraq after the war. This benefits the US because it conceals the main issue of wide ranging chemical damage effects from blown up oil wells and oil refineries that used HF and the oil products that damage the GSH and SOD in the human body. There is no possible way that the use of DU in Iraq has caused the wide spread illness effects in the civilian populations. On the other hand, there is little doubt that DU is directly involved in affecting the health of persons that cleaned up DU hits on vehicles, those that stirred up the DU dusts hunting war souvenirs, and some of the Iraq population in close proximity to high level DU contamination. DU oxide dusts of the nano-meter size particles easily gain entry to the body via skin and via lung and has toxic characteristics similar to mercury. The DU issue is being politicized to hide the very much larger problems of chemical effects on GSH and SOD. The chemical damage factor to GSH and SOD causes the DU retention time in the body (or the biological half-life) and ROS damage to be greater, and the same effect applies to all other toxic metals.
All of the studies for DU's biological half life is done on healthy animals with normal levels of GSH and SOD, and without the mercury toxicity effect on renal cells. When chemical damage to the GSH and SOD levels in the body is included for the increased toxic metals damage to kidney calls, the biological half-life of DU and other metals is made much longer. The use of mercury in vaccines helped to impair kidney cells and the damage is high as mercury also suppresses GSH and SOD. All the GWI studies that use the single challenge DU exposure for the biological half-life numbers that don't include the chemical damage to the enzyme clearance of toxic metals are in error. With the reduction of GSH and the bile pathway comes high loading of the renal cells with DU, Hg, and other toxic metals that damage these cells and set up higher levels of toxic metals retention in the body due to highly impacted losses of the two main clearance mechanisms.
The DU armor on US tanks is sandwiched between sheets of aluminum and when the material is hit, not only DU dusts come off but Aluminum dusts do also. The aluminum dusts pose an even worse health risk than the DU, because they form the AlFx compounds in the body that upset the TSH pituitary regulation process and the prime factor that triggers GWS via GSH depletion. These exposures would add on top of the aluminum in the vaccine exposures.
The War in Iraq also is one of political affectations, rather than any real threats against the US. Bush-41 holds a huge interest in the Kuwait oil fields and he was the first US operation to open up Kuwait's oil fields. Iraq was considered a threat to Israel and the Jews. Government engineered the Iraq conflicts for Israel's interests and not those of the US. In so doing, persons have killed some 400,000 effective lives in the US and cost the US trillions of dollars for the interests of a foreign power that has little interest in the US other than trickery to promote their own group aggrandizement interests. Big oil person Condi Rice, who was trained by Madeline Albright's father in Denver, Co., is part of the Jewish problems. Oil is being used by Israel to leverage US into doing their bidding. Even the 911 event was about Israel's agents helping to facilitate the WTC attacks and helping the Arab factions pull off the attacks. The pattern that has gone on since the times of JFK's death fits the Mossad Logo that Reads: "By Way Of Deception Thou Shalt Do War"
The Persian Gulf Wars are all about the concepts of deceit and treachery and this method is being used to conceal the main health effects of GSH and SOD damage via chemical effects on enzymes. The effect is most pronounced for hydrogen fluoride systemic poisoning effects on enzymes using metals. This simple and very basic of effects is the principle damage vector to most all persons health in the US and the very roots of the system of profits for the AMA based medical system. When this very basic system for cause and effect on health becomes exposed, large parts of the medical system in the US will be tossed aside as being too expensive and insensible. Again, the main cause of Gulf War Illness and the very war itself is about politics and money and not about any mystery causation.
The very roots of the GOP dominated industry is on the very verge of being found out for the degrees to which they have abandoned citizens health to favor making uranium, aluminum, and other strategic metals to gain control via wars. Long ago the US decided to cover up this major cause of ill health in the US and use AMA medicines to mask the symptoms and control the damage factors. The Rockefeller based AMA and big oil is right in the middle of the cover-ups. Even religion, which is highly GOP oriented, is being used to help cover up the health associations from toxic emissions that appear in the biblical times.
The very same diversion tactics have been used in Oak Ridge to conceal the HF dominated health damage to workers and area residents health. In Oak Ridge radiation and heavy metals are played up as the direct cause for what is causing everyone's health problems. The real problem is a two step progression due to chemical damage from HF, PCB, and Hg to enzymes GSH and SOD leading to factors that look like radiation damage effects to cell enzymes that regulate viruses and cause the rise of toxic metal retention. Oak Ridge uses deception to protect themselves from the massive lawsuits and the Govt. payout for the health damage their operations have caused to a large area in and around Oak Ridge. The local medical system uses the large-scale cover up of the problems as a reason to make great profits treating all the additional illnesses and dispensing large amounts of drugs to those affected. Oak Ridge has long had an understanding with the local medical community that they won't disclose the main causes of illnesses or diseases, if they associate in any way to the DOE operations in Oak Ridge. It is this same system of ultimate deceit and treachery used to fool the citizens that has been extended to those veterans of the Gulf Wars and the people of Iraq and other sites where the toxic soup factors have become extreme.
Both GSH and SOD are liver oriented enzymes and required in every cell to work properly. GWI's prime cause and effect leads off with chemical damage to the liver's production of GSH and SOD. When this liver enzyme system is chemically poisoned the body's toxic metal load begins to increase and as this occurs these toxic metals interact with the cell mitochondria that then causes the increase in the ROS levels within the cells. It makes perfect since that these two areas would become the first affected, as these are the most vulnerable areas for chemical and metal poisoning effects on the body. The very same effect occurs with aging, as levels of these enzyme poisons rises in the body with age.
Even the factors of high rates of ALS seen in the GW vets is directly associated with the GSH and SOD enzymes. ALS is associated with upsets of copper and manganese that form these enzymes. The problems of Mad Cow and Prion linked illnesses are caused by these same factors. Mad Cow effects come from a systemic shift toward Mn-SOD from the Cu-Zn-SOD, and loss of Mn dependent enzymes that cleave viral RNA within cells. When sulfur bearing compounds like DMSO are applied to Mad Cow affected brain tissues, the plaques dissipate, and DMSO appears to act as GSH in supplying the sulfur to remove the toxic metals from the brain that attract the SOD needed for myelin repair.
For those of you who want to look more deeply into the issues of how GWI
and CFS are well association let me recommend reading this better documented
piece at:
"http://www.doewatch.com/cfs.html"
and see this for more fluorine details:
"http://www.doewatch.com/f.html"
This health problem's main vector from damage to GSH and SOD has been long known back in time and is part of the story of Prometheus and damage to the liver from exposure to volcanic emissions, HF. Hercules rescued Prometheus from liver damage problems is the heart of this same health damage vector. If one notes, the Prometheus figure is part of Rockefeller Center in New York City, and this same mechanism is what makes the doctors of the Rockefeller AMA based system their wealth. The main problem of GWI is the greed of GOP oriented system of AMA profiteering by suppression of how industry poisons the GSH and SOD liver enzymes leading to immune related illnesses in the population.
The Prometheus story is the Greek version of health effects from nature's emission of toxic materials, but versions of the same theme carry back in time to the stories of Noah and Moses, and their very similar volcanic associated health effects. The major problem blocking the real story on GWI being told by the US Govt. is all about near total corruption in US politics and the US version of religion based on alterations from the truths of the old biblical narratives.
This is an effort to make the real story public, as we survive in each other's care. The real story here is about being dutiful toward the people of the US and not its corrupted operations that attempt to deceive the people from the truth. It is these untruths in religion and cover ups in health that are at the very roots of the terrorism equation, which Israel and the GOP exploit to the harm of every citizen in the US.
The People of America have never been so disenfranchised from control of their Govt. nor the US Constitution as threatened as now from this corrupted political and religion process. The entire US system is at risk from these cover-ups in health linked to industry emissions and racketeering process used to hide the massive problems.
REFERENCE CITATIONS:
Title
Role of glutathione and hepatic glutathione S-transferase in the biliary
excretion of methyl mercury, cadmium and zinc: a study with enzyme inducers
and glutathione depletors.
Author
Gregus Z; Varga F
Source
Acta Pharmacol Toxicol (Copenh), 56(5):398-403 1985 May
Abstract
The effect of hepatic glutathione (GSH) depletion and enzyme induction on
hepatic glutathione S-transferase (GST) activity, biliary excretion of GSH,
methyl mercury, cadmium and zinc was studied in rats. The GSH depletors,
methyl iodide and diethyl maleate, did not influence hepatic GST activity
but, depending on the substrate used, benzo(a)pyrene, phenobarbital,
pregnenolone-16 alpha-carbonitrile (PCN) and trans-stilbene oxide (TSO)
increased it by 16-33, 44-89, 53-97 and 208-279%, respectively. GSH
depletors decreased (-88%), benzo(a)pyrene and TSO did not affect,
phenobarbital and PCN increased (+113 and +149%) the transport of GSH into
bile. The biliary excretion of methyl mercury, cadmium and zinc was reduced
by GSH depletors (-97, -74 and -93%), and enhanced by phenobarbital (+139,
+280 and +220%) and PCN (+150, +121 and +160%). Treatment with
benzo(a)pyrene and TSO did not affect the excretion of methyl mercury and
zinc into bile, but decreased that of cadmium. These results do not provide
evidence for the role of hepatic GST but strongly support the importance of
biliary GSH excretion in the hepatobiliary transport of methyl mercury,
cadmium and zinc. It is assumed that phenobarbital and PCN enhance the
biliary excretion of these metals by increasing the transport of GSH, the
carrier molecule, from liver to bile.
Title
Effect of lipoic acid on biliary excretion of glutathione and metals.
Author
Gregus Z; Stein AF; Varga F; Klaassen CD Address Department of Pharmacology'
University Medical School of P]ecs' Hungary.
Source
Toxicol Appl Pharmacol, 114(1):88-96 1992 May
Abstract
Several metals are excreted in bile as glutathione complexes' and their
biliary excretion is facilitated by increased hepatobiliary transport of
glutathione. The present study analyzed the effect of lipoic acid (LA;
thioctic acid; 37.5-300 mumol/kg' iv)' an endogenous disulfide which can be
reduced in vivo to a dithiol' on the hepatobiliary disposition of
glutathione-related thiols and the biliary excretion of metals (10 mumol/kg'
iv) in rats. Administration of LA enhanced the biliary excretion of reduced
glutathione in a dose-dependent fashion. Despite increasing glutathione
output' LA (150 mumol/kg' iv) did not increase' but rather decreased' the
biliary excretion of methylmercury' cadmium' zinc' and copper' which are
transported into bile in a glutathione-dependent manner' as indicated by a
marked reduction in their biliary excretion after diethyl maleate-induced
glutathione depletion. In contrast' biliary excretion of inorganic mercury'
which is minimally affected by glutathione depletion' was dramatically
enhanced (12- to 37-fold) by LA administration. Following inJection of LA'
the concentrations of endogenous disulfides in arterial blood plasma (e.g.'
cystine' glutathione disulfide' cysteine-glutathione' protein-cysteine' and
protein-glutathione mixed disulfides) were considerably diminished' while
the levels of endogenous thiols (e.g.' glutathione and cysteine) were
increased. This finding indicates that LA' probably after enzymatic
conversion to dihydrolipoic acid' can reduce endogenous disulfides to
thiols. It appears that LA induces the transport of glutathione into bile by
the temporary formation of dihydrolipoic acid-glutathione mixed disulfide'
which after being translocated into bile is cleaved to LA and reduced
glutathione. Because the glutathione molecule thus transported into bile
cannot complex metals at the thiol group' this might be the mechanism for
the observed failure of the LA-induced increase in biliary excretion of
glutathione to enhance the hepatobiliary transport of metals that are
transported into bile as glutathione complexes (i.e.' methylmercury'
cadmium' zinc' and copper). The observations also raise the possibility that
endogenous dihydrolipoic acid' by forming a stable complex with mercuric
ion' may play the role of a carrier molecule in the hepatobiliary transport
of inorganic mercury.
Title
Biliary secretion of glutathione and of glutathione-metal complexes.
Author
Ballatori N; Clarkson TW
Source
Fundam Appl Toxicol, 5(5):816-31 1985 Oct
Abstract
As bile is the main route of elimination of many metals, a large number of
studies have been directed toward the characterization of the hepatobiliary
transport of both endogenous and exogenous metals. Although some progress
has been made, we still know little of the basic mechanisms involved in the
hepatocellular uptake of metals, in their intracellular translocation and
metabolism, or in their transport into bile. Our recent studies have focused
on the last step in the hepatobiliary transport of mercury, namely, the
secretion of the metal from liver cells into bile. The rate of secretion of
methyl and inorganic mercury into bile was low in suckling rats and rapidly
increased to adult rates soon after weaning. These changes closely followed
similar developmental changes in the biliary secretion of reduced
glutathione (GSH). When GSH secretion into bile was completely inhibited,
without changing hepatic levels of GSH or mercury, mercury secretion was
also completely blocked. mercury secretion paralleled individual and
sex-related differences in GSH secretion. At the same time, the secretion of
mercury was independent of bile flow, of the thiol and mercury concentration
gradients between bile and liver cells, and of those between bile and
plasma. Our results, therefore, indicate a close coupling between the
secretion of mercury and that of GSH. These in vivo findings, along with in
vitro studies by others in vesicles isolated from the canalicular membrane
of the liver cell, indicate a carrier-mediated transport system for GSH, but
the nature of the linkage of this transport system with mercury secretion is
not yet fully established. Our data and those in the literature are
consistent with the involvement of at least two steps in the movement of
mercury from liver cells to bile--the formation of a mercury-glutathione
complex in the liver cell, followed by the secretion of this complex through
a process closely linked to GSH secretion. The identification of GSH as an
endogenous complexing agent in the transport of metals between tissues and
body fluids now permits the design of therapeutic strategies aimed at
exploiting this transport vehicle to effect the removal of metals via
physiological routes of excretion. The present discussion considers the role
of GSH in the hepatobiliary transport of metals. In doing so, a brief review
is given of current understanding of hepatic GSH metabolism and transport.
Diagnosis: Environmental Toxic Pathway Analysis and Immune System Cytokine Modality Provide Key Insight into Chronic Fatigue Syndrome Mechanism and Etiology of Varied Pathogen Driven Illnesses.
Abstract:
The human immune system is a complex system of dynamic cells with many cytokine feedback factors that have been explored in the last decade to reveal many of the mechanisms for illness. The immune defense takes on two distinct modes as set up by the stimulation of T helper cells, as triggered from the lymph nodes. The cellular Th1 immune system profile is one designed to control pathogens internal to cells and the humoral Th2 system response controls external cell pathogens.[1] Study of the cell factors and cytokine signaling yields an understanding of how these factors lead to and control many illnesses, including chronic fatigue syndrome (CFS). This report outlines a cellular mechanism and a toxic pathway for damage to the immune system by analysis of the cellular cytokine response from toxic damage, which then leads to more progressive disease factors from loss of pathogen regulation.
This discussion will time line the discovery of CFS, correlate toxic environmental factors with CFS, and connect the cell mechanisms to the prime factors driving the CFS immune dysfunction process. The nuclear weapon materials research offers key insight into the toxic pathways and cellular responses that lead to these theories and conclusions. This report reflects my research into viral and immune system effects since 1980, with direct experience from the Oak Ridge, Tennessee nuclear site. I, as an ORNL Sr. Staff, proposed that fluoride in bone had an insoluble precipitate effect, a metals speciation, on the essential trace metals for immune cells formed in the bone mass. The effects of fluoride forming G-proteins would lock up and shut down the lymph node immune defense process. Fluoride is a potent enzyme poison due to its affinity toward trace metals. This key effect has not been reported by ORNL and has been suppressed since 1986 due to Oak Ridge liabilities from toxic HF emissions. Presenting a key finding on fluoride toxic effect and its cumulative mechanism in a public forum is the purpose of this report.
This report is principally concerned with the lymph system, its cytokine signaling, and how it responds to toxic exposure. Cell and lymph system response is nothing new as even snake venom toxin drives cytokine response and nitrogen oxide (NO) generation.[2] Snake bites require light tourniquet pressure to prevent circulation of snake venom in the lymph system and around the body leading to death in some cases. Many biological toxins are handled well by the lymph system, but many toxic materials enter the same pathways and cause serious problems due to insolubility problems of mineralization or turning to stone in these critical zones. Oddly enough, it has been suggested that the symbolic imagery connected with the Virgin Mary icon standing with foot placed on a snake emanating from the Earth and the snake biting the apple as symbolism for contamination from the Earth's lower regions connected to disease and illness. Religion symbolism from Noah is connected to the largest land mass volcano on the Earth and the toxic emanations to health effects on man and animals. Religion and Revelations even speak to the asteroid called "wormwood" that poisoned the planet with volcanic like toxins from the heat of interactions from land impacts, or caused massive floods when they impacted oceans. This report will take a multi-disciplined investigation, using volcanology, asteroid terminal event toxic releases, history, religion, nuclear plants, wars, and toxic research to look more deeply into these health effects.
From the nuclear weapons production, Oak Ridge is one of the most chemically impacted industry sites in the U.S. and many toxic linked illness patterns are evident. The toxic material research studies from the nuclear industry and Oak Ridge health problems provide a clear and unique view for some of the mechanisms for toxic driven immune activation in illnesses. These studies, that are well known in the nuclear plants, will be used to illustrate and prove the process of toxic induced immune illnesses. Toxic material pathways into the human body, how they retain or concentrate with time, and vector to different organ systems play pivotal roles in disease etiology. Some of these toxic material pathways directly affect the immune system resistance and lead to viral disease etiology. Examining these patterns and how they overlap CFS is the focus of this report.
The term "CFS" (or CFIDS) made its national appearance in the mid 1980's with the investigations of Dr. Paul Cheney concerning sick persons in the area of Lake Tahoe, on the California and Nevada border. Most of these CFS persons were fine one day and came down with mononucleosis like illness the next, with flu like symptoms persisting. In 1999, Cheney described the illness as one that depleted glutathione, used much ATP, and showed a very significant up regulation in an enzymatic pathway known as the 2-5A RNase L.[3] Looking for toxic exposure factors, the waters of Lake Tahoe are pristine, but the area is of volcanic origin that contaminate some wells and soils with volcanic materials. Well waters are often contaminated with higher levels of arsenic, manganese, radium, radon, and fluoride than surface waters. South Lake Tahoe has public water supplies from wells that have metal contamination, often associated with volcanic zones or mining. South Lake Tahoe water reports have specific caution for immune compromised persons because of these pollutants.[4]
Cheney's CFS Tahoe cluster diagnosis was made possible by detection of new chemical bio-markers, but CFS is not new as it appears to be symptomatically reported in 1750 and in other terms in earlier periods.[5] It is also speculated that the biblical story of Jesus healing the person by the well is even earlier evidence of the illness. The Cheney / Tahoe mononucleosis like illness is associated with swollen lymph node from activation of EBV, HHV-6, and other viral pathogens that are associated with follow on disease factors, like MS.[6, 7] Glutathione (GSH) depletion is associated with the cellular oxidant repair process and detoxification of tissues and it is lowered by chemical and pathogen damage to mitochondria of cells that manufacture ATP.[8, 9] Lowered GSH can hasten cell apoptosis and is an indicator in chronic disease, cancer, arthritis, and rapid aging.[10, 11, 12, 13, 14, 15] Glutathione is important in liver detoxification and in maintaining the mucosa cells that line the intestine.[16, 17] Selenium associated Glutathion depletion drives shifts in cytokine mode from Th1 to Th2.[18]
The "2-5A RNase L" enzyme is part of the activation process for the Th1 interferon cytokine that inhibits viral replication in cells.[19] 2-5A RNase L is also important in the control of HIV replication.[20] These bio-markers point out that control of viral pathogens in the body have been compromised. The mechanism from just these indicators is not well defined, but these are indicators of immune cell toxic effects. There is a enzyme chimera effect for CFS associated 2-5A RNase L where persons with CFS produce a 37 kDa enzyme inside their white blood cells, where normal persons produce a slower but more effective 83 kDa enzyme. The lighter weight enzyme is faster in dissemination, but less effective in killing viral components. The damage to the RNase L enzyme follows damage to GSH and SOD, which clears toxic metals that damage mitochondial function, produce excessive ROS generation, and reduce ATP production.
The appearance of this lighter weight chimera of the 2-5A RNase L enzyme sets up the factor for viral infections and in white cells not being controlled. The 37 kDa enzyme does not kill viral presence inside cells, nor does it kill many of the white cells. This is the key to transmission for the viral spreading in the white cells of the immune system and infecting many cells in the body. The rise in the RNase L causes damage to the mitochondria and ATP production. It also sets up the causation for the high levels of NO in the cells that damage the mtDNA. This effect sets up the debilitating fatigue connected with CFS that follows directly upon the RNase L chimera. The principle question then becomes what causes this enzyme of the white cells formed in the bone marrow to mutate into a lesser effective enzyme.
The basic mechanism of cell enzymes that police viral and pathogen infections inside the cells is also seen from high radiation effects. Typically the high ROS produced by external gamma radiation will result in cell infection problems that are treated with antibiotics. Mycoplasma's, viruse's, and bacteria's become problems when RNase L becomes less effective due to high rates of ROS damage. The very same effect on RNase L can be had from the loss of GSH and SOD due to chemical factors acting on G-protein channels shutting down its production. In this way, chemical induced free radical damage and radiation induced free radical damage are the same and additive toward damage to the RNase L. Cancer tumors occur from the activation of endogenous DNA viruses and the mutations of those viruses the radiation induces. Vaccines also included cancer viruse like SV-40, which can become active when cells loose their RNase L enzyme protection. When the Rnase L enzyme is impaired by free radical damage, cancer viruses can proliferate and even produce their own GSH and SOD to promote their growth. Cancer viruses also promote cytokine TNFa which sets up higher blood circulation that helps the tumors grow more rapidly. Cancer virus and tumors proliferate only with ROS damage to the RNase L enzymes impair the process that causes cell apoptosis or death AND when the back up system of Th1 cytokine signaling impairs the macrophage and T-cell protection system. Both failures often hinge on damage to GSH and SOD from chemicals affecting the GSH G-protein channel.
Cheney's patients were from an extinct volcanic zone with contaminates in well water. From the study of volcanology, we know volcanic zones have many of the toxic fluorides and metals problems associated with mining and operation of Department Of Energy (DOE) plants that emit metals and fluorides.[21, 22, 23] Volcanoes have more explosive power from H2S than nuclear weapons and produce toxic fallout and contamination problems with acids, toxic metals, and toxic halogen compounds [i.e.: calcium fluoride, hydrogen fluoride, hydrogen chloride]. Meteor events also present toxic emissions like those from volcanoes and these same factors play dominant roles in species survival. Meteors that hit the oceans cause massive waves as in the times of Moses flood, and those that hit the land mass produce huge levels of very toxic acids like HF. The Earth, for many millennia, was bathed in distilled waters from the heat of the sun that produced a thin layer of less toxic soils on the planets surface and clean surface waters. Mining, industry, and well drilling often compromise this natural toxic isolation process and lead to health problems in man.
Volcanoes and glacial effects have long been associated with essential trace metals availability in soils. Soils in the US and other areas have been highly depleted of these essential trace metals by over farming, over grazing, and by acid rain effects. Before man's energy needs the chemical speciation and solubility factors for these trace metals was determined by sulfur from volcanic emissions. As man's energy needs have become dominate; the hydrochloric, carbonic, and nitric acid effects have grossly upset the metals speciation from that of sulfur dominated. This highly affects grazing animals health that are highly coupled to the soils via the grass uptake of these trace metals. The change in metal speciation puts more toxic and dangerous metals into the grazing animal's diets and with this effect comes the "mad cow," scrappie, and prion linked problems we see today. One can easily find cattle being highly affected by toxic aluminum, increased manganese, mercury, and other metals offset. In the US, the practice of feeding cows bone meal had to be stopped because the bone sequestered these toxic metals and fluorides and this was linked to the prion formation.
Toxic emissions from volcanoes have been associated to bio-markers such as porphirine and porphyrins, which are diagnostic indicators of toxic cell damage effects from metals and chemicals.[24] Porphyrin is the killing chemical inside NK cells and when these cells are destroyed it releases higher rates of the porphyrins in the blood. CFS causes lowered NK cell population and this is a result of their porphyrin content and RNase L ineffectivity toward viral infections. Persistent toxic gas emissions of volcanoes kill animals and cause long term defoliation of downwind areas. This is often connected to chemical damage effects to GSH and SOD enzymes, which increases retention of toxic metals and ROS damage in cells. Mining and smelting operations often cause similar problems with acid run off contaminating soil and water with metals and fluoride. It should be noted that century's earlier volcanic zones were connected with rapid spread of disease. An example is the Hawaiian Islands and their native residents weakened immune resistance to measles, syphilis, and other diseases, as Europeans traded and socialized with them. It is noted in history that in this population disease spread incredibly fast and devastated the islands inhabitants, which suggested their immune resistance was degraded by their volcanic environment. Volcanic eruptions are even postulated to have caused the downfall of the Egyptian City of Memphis from massive plagues. It was these early associations that connected toxic material to the weakening of the immune protection system making persons vulnerable to opportunistic infection and endogenous viruses in the body, as well as exogenous viral transmission. These early observations suggested CFS had environmental and industrial linked toxic contamination origins.
In other centuries toxic metals such as arsenic, lead, and mercury were associated with health effects. Lead was connected to the neurological hearing illnesses that Beethoven experienced and even associated with the demise of the Roman empire due to the lead food storage methods.[25] Lead promotes a Th1 type cytokine response and tumor necrosis factor alpha (TNFa) that will activate the macrophage's and pull particulate into the lymph nodes.[26] The leading Th1 cytokine called TNFa promotes macrophage activation. Persistent triggering of Th1 inflammatory cytokines by toxic materials is linked to CFS factors like headache, fever, myalgia, fatigue, and are toxic in high doses. Here the pathway was via food supply with absorption via stomach and gut and retention of metal oxides in the local lymph nodes. Toxic metal retention and damage to the immune system is associated with cancer vulnerability.[27, 28, 29] The effects of arsenic in well water are associated with the rising cancer rates in India. It was attempted to improve the biologically polluted, surface public water supplies in India via drilling wells, but this resulted in high arsenic public water. Arsenic is well connected to lung, bladder, and skin cancer, but is a treatment for liver cancer that impairs the mitochondria of cancer cells.[30, 31] A similar attempt to avoid biologically contaminated surface water in Africa presented wells with high fluoride content. How these toxic materials distribute in the body organs and inner cell effect is important to immune resistance. A dominate factor for metals retention and lymph node build up is linked to chemical damage to two essential enzymes, GSH and SOD, which convert metals to sulfides and excrete them via the liver's bile pathway.
A metal oxide analogy from the mining industry is connected to the mechanism of a controversial anti-cancer drug called laetrile. In special mining practices, cyanide chemicals are combined with insoluble metal oxides in a process called in-situ mining to form extractable soluble metal products. The cyanide radical makes metal oxides soluble via replacement of the oxygen radical. The cyanide radical is unique in its ability to render metal oxides soluble and the effect is used in mining for various metals and in the electroplating process. Some enzyme processes mimic this effect in human chemistry. Cyanide radicals are also drawn into the lymph nodes, where the increased probability to react with metal oxides may reduce their concentration. Lessening the lymph node concentrations of insoluble metals then linked to the anti-cancer effect by restoring lymph node cell function. It is suggested that the biblical symbolism of turning to stone is a version of these metal oxide ore minerals forming stone and impairing the lymph system. The function of the immune system is central to the control of cancer viruses, yet many studies are done with only the cancer tumor cells in mind. The laetrile studies omit the immune system effects and the metal loading effects in the lymph nodes. Many B vitamins are also cyanide involved compounds that may play a role in the metal detoxification process. Vitamin B-17 and laetrile share the cyanide radical. Many grains contain B-17 and over processing of foods tend to denature the natural beneficial content. These vitamin processes are highly controlled by the GSH enzyme's availability. Food processing and cooking often deplete food of vitamins, enzymes, and cyanide compounds. In the last 50 years, the industrial dominance of metals in immune damage has been replaced by more dominant chemicals, such as fluorides.[32, 33] This makes the effects of laetrile of lesser benefit in cancer treatment. When fluoride enters the picture, damage to the GSH and SOD process become dominate in the toxic metal retention and ROS cellular damage process.
These simple observations began my thesis for the mechanism for disease from the impact of toxic metals on cells in the early 1980s. These observations qualify that many toxic metals are linked to disease, now it remains to determine what quantity and what processes are involved. It was observed that many toxic heavy metals damage cells and activates immune system response. The toxic cell damage triggers cytokine production and T-cells that kill the damaged cell with hyper-oxygen products and trigger macrophage's, which clean up the material and process it with hyper-oxygen reduction chemistry.[34] The process results in the accumulation of insoluble metal oxides in the macrophage region of lymph nodes and can be seen in data from many toxic metals. This biological accumulation of toxic metals is seen in the research data for beryllium, silicon, plutonium, uranium, and other insoluble metal oxides.[35, 36, 37] The effect is very clear in research for lung damage from airborne toxic metals pathways to lung that activate the lung inflammatory immune response. Toxic materials in the lung activate the cytokine production of TNFa that promote macrophage's, and can be seen with radiation and for toxic metals. [38, 39, 40] Cytokine TNFa is directly delivered to the mitochondria of cells and involved in apoptosis / necrosis.[41] The mitochondria of cells play important roles in cell energy production and hormonal and cytokine messaging.
Beryllium is the most detailed studied toxic metal and makes an excellent example for the model of how a toxic metal activates the immune system.[42] Beryllium workers can become sensitive to beryllium and become sensitized to breathing it as determined by a lymphocyte proliferation test. With any addition exposures persons can acquire a fatal disease called chronic beryllium disease, where the lungs cells are damaged by continual inflammation. This is often mediated with steroid inhaler medication. The disease is often mis-diagnosed as asthma initially due to similarity of symptoms. Beryllium is taken into the lymph nodes via the action of macrophages and as the lymph concentration builds it triggers the lymph nodes to make T-cells and B-lymphocytes in response to the toxic beryllium metal.[43] As the concentration in the lymph nodes builds the insoluble metal oxides retain long term and keep the local lung lymph system triggered long term in the Th1 inflammation mode. In this Th1 State the lung uses much glutathione for cell repair processes.[44] The key element for beryllium disease is that beryllium-fluoride compounds are the worst and this effect is tied to the issue of their BeFx G-protein effects toward shutting down GSH and SOD production within cells. The effect shuts down the prime clearance enzyme for the beryllium and the cell ROS repair process. The air pathway for beryllium used in the nuclear weapons business is a well developed model for the immune activation process, and shows a local process that is highly related to indicators seen in CFS. Sensitization to beryllium compounds happens after cells in the lymph nodes undergo blast cell transformation. It is clear that beryllium concentrations of beryllium toxic metal in lymph nodes set up the cytokine triggering of the immune system.
Beryllium and fluoride can combine either in manufacturing processes or spontaneously inside the human body. Beryllium and fluorine combine to form dangerous BeFx and AlFx compounds that mimic G-protein triggers for human immune cells. The fluorine atom is the most electronegative of the elements and when bonded to these cell sites it cannot be undone. The vaccine business uses a similar technique with vaccine adjuvants made from aluminum [aluminum hydroxide (alum), aluminum phosphate], which forms an AlFx complex that also mimic the G-protein trigger effects.[45, 46, 47] Here the effect seeks to program the lymph node dendritic cells for long term memory of the vaccine and shift to Th-2 cytokine dominance. It is this effect that tends to lock on the immune system memory and set up long term immune sensitivity to metals like beryllium, and cause the immune system's tolerance for varied pathogens to become negatively affected.
Man's industrial effects have produced a systemic shift in the nature of the planet's processes that have resulted in a serious problem for the immune system. The rise of HCl in the environment has freed more aluminum into the food chain, and man uses aluminum in many places from salt and baking powder to vaccines and toothpaste. Fluoride has risen in the environment and into man due to similar aspects. Fluoride in the body tends to spontaneously interact with trace metals and can form the AlFx compounds that trigger the cellular G-protein channels that shut down GSH and SOD production. Man has also introduced dioxin, PCB, Hg, DDT and other chemicals that have risen in man's body and that interfere with the G-protein channel that regulates GSH and SOD cell production. 80% of the drugs make in the US are directed at controlling G-protein channels in cells that correct for these toxic induced effects on GSH and SOD. It is a multi-trillion dollar industry, where one system pollutes and causes illnesses, which the other attempts to correct for the toxic induced damages using pharmacology methods.
Other toxic metals cause the same problems at concentrations lower than that needed to kill the cells directly, as long term cytokine activation causes serious health problems.[48] As the metals concentrations build in the lymph nodes the TNFa cytokine causes necrosis of the macrophage and other lymph nodes cells and continual generation of activated T and B cells. If the lymph node concentrations get too high this disables the pathogen destruction function of macrophages. Beryllium oxide particles principally involves the local lung lymph nodes, but other toxic metals that are more soluble and enter the body via air or food chain can impair lymph nodes near the intestine or all the lymph nodes at once. As the macrophages are disabled it leaves cell fragment products scattered around the tissues that then bias the system toward a Th2 response in the long term. Th2 modality excretes IL-10, which further shuts down the macrophage function and exasperates the effect. This leaves the body vulnerable to inner cell viruses and other pathogens such as mycoplasma.
Metal prosthetic joints in the body further illustrate the effect of metal particulate concentrating into the lymph nodes and this triggering inflammatory cells that loosen the bone with high levels of peroxides.[49, 50] Metal particles of less than 1 micron can be carried into the lymph nodes via the macrophage's and concentrate there.[51] The lungs are sensitive to many different metal particles that can also set up the Th1 inflammation mode. The effect is intensified if the particles from airborne exposure have an acid like coating that is insoluble. Regulations have attempted to mediate these toxic particle exposures, but has made further poor choices. Gasoline refining eliminated lead in the 1980's because of this effect on the population and replaced it with hydrogen fluoride (HF), which has even worse cumulative factors and time integral dose effect on the macrophage function. Rising levels of pesticides in food and water, rising industrial emissions of HF all combine to contribute to effects of GSH and SOD reduction leading to toxic metal retention that trigger the cytokines and lead to CFS cytokine Th2 modality in the long term. The worsening environmental metal effects can be seen in even the surface waters of the Great Lakes with their increasing levels of toxic metals that can damage the immune system, produce allergy, increases susceptibility to disease, and autoimmune disorders.[52] Even pollution of rivers from fluorides added to public water supplies harm salmon.[53] Animals and man can be highly affected by toxic metals and their phagocytosis cell ability severely impaired by low concentrations of metals, while NK cell activity is not impaired.[54] It is these poorly controlled pollutants that drive increasing rates of CFS, cancer, and many immune linked illnesses.
The key etiology of the toxic accumulation effect can be anticipated by the function of oxygen based chemistry of stationary macrophage's in the lymph nodes acting with the mobile macrophage's carrying toxic cell material from around the body to these local lymph zones. This is an often overlooked important and key effect to have build up of insoluble toxic material directly in the critical signaling network of lymph nodes that keeps the immune system cytokine triggered and supply high oxidative stress directly in the lymph nodes. This effect can lead to toxic metals damaging the ability of the body to control pathogens and even to rising viral presence in the body from endogenous and exogenous sources.[55, 56] For air pollutants the lungs nodes are most affected and for food and water pollution the stomach and intestine nodes are the principle effect zones. A pivotal role is carried by the proper function of the lymph node pathogen regulation mechanism. Simple local inflammatory activation of the immune system results in increased glutathione to aid in DNA repair, and long term global activation results in depletion of glutathione. Decreased levels of glutathione promote cell apoptosis / necrosis. Toxic's that damage the liver cause a lack of glutathione for DNA repair.
The importance of a cell organelle called the mitochondria was better defined with respect to disease mechanisms in the mid 1980's with its critical role as the cell energy mechanism and the source of ATP.[57] These organelles were small cells within cells with bacterial like DNA that were vulnerable to oxidation effect, metals, and oxidative halogens.[58] GSH plays a strong role in the production of ATP and mtDNA repair from oxidative damage.[59, 60] CFS is well connected to lowered ATP levels.[61] Mitochondrial damage is connected to nerve damage and aging.[62, 63] Mitochondria is how the body converts stored fat into energy and damage to these areas of cells is linked to weight gain and obesity factors that are high in the US. Fluorides have the capacity to affect the thyroid T-3 hormone production and modify cellular ATP production throughout the body as well as diminish mitochondrial numbers in cells.[64] Depletion of ATP is connected to the Th1 to Th2 switch seen in CFS and other diseases.[65] High concentrations of toxic metals and fluorides in the lymph nodes will highly impact the mitochondria of these cells. This leave little doubt that the worst case for mitochondria damage due to toxic concentrations is the lymph nodes and that this process is directly connected to CFS and other immune dysfunction illnesses.
The role of GSH and SOD and the involvement with mitochondria and ATP explains the issue of "radiation hormesis." Radiation hormesis was seen in areas like Japan after the bombs were dropped and it promoted more rapid tree growth as shown by tree growth ring data. The increase in radiation in the area promoted the cells and its feedback systems to call for more SOD to be produced to handle the free radical damage effects. SOD and GSH go hand in hand in plants and to increase SOD the GSH levels are naturally increased as well. The high GSH levels cleared the toxic metals from the cells to greater extents that promoted less destructive mitochondria interaction from the metals and greater amounts of ATP generation. The higher levels of ATP promoted more rapid cell growth and is the interaction mechanism for radiation hormesis.
The enzymes GSH and SOD are also the prime clearance and repair mechanism for the brain. Altered levels of GSH and SOD are tied to all of the mental illness problems, and also to factors of Alzheimer's, Parkinson's, and etc. It is well known that the metal lithium is used in the treatment for mental illnesses and what the lithium drugs promote is higher levels of SOD being made in the cells to repair the ROS damage to cells. The ROS damage to cells stems from toxic metals like mercury or the combination of aluminum and fluorine forming the AlFx type G-protein. The lithium atoms are believed to interact with other metals in the G-protein channels that direct the production of SOD by the cells. This process of lithium on SOD appears to not up-regulate the GSH levels needed to clear the brain of the toxic metals, so the lithium drugs have to be used often to control the mental illness.
One of the prime CFS symptoms is that of frequent diarrhea and this again is associated with the levels of GSH and SOD in the cells of the gut walls. Persons with CFS and GWI generally have impaired levels of GSH and SOD enzymes. This effect is made much worse in the local area of the gut when these persons drink excessive levels of sugar-laden colas or other sugary foods. Processed sugar is a GSH and SOD antagonist and this promotes high levels of free radical damage to the cells of the gut wall. The high rates of free radical damage causes the gut cells to sluff-off with lots of water much as a blister type effect from a burn. The same type effect occurs from the radiation intestinal death effects for acute radiation doses that make the same levels of ROS damage to the cells. The extreme damage from the high levels of ROS damage also cause damage to the blood vessels in the colon and cause bleeding hemorrhoid problems and loss of blood and essential trace metals. The high levels of ROS damage in these local cells also damages the Mn dependent 2-5A RNase L enzyme resulting in lots of local cells having active viral infection problems that involve the local lymph system. The problems of reduction in the cell production of GSH and SOD well define the mechanism of problems like persistent diarrhea and even the issue of loss of cognitive abilities from similar problems in the brain.
These intestinal effects are even spoken of in the Biblical Narrative with recognition of guts like stinking sulfur bogs. The Biblical Narratives also speak to the use of the plant called "Aloe Vera" as a type of medicine. Aloe Vera has very high levels of both the enzymes GSH and SOD. The high levels of SOD in the plant is why it is often used so effectively to treat burns, as it corrects for the free radical damage effects to cells. Persons seeking to correct for the free radical damage of their intestinal tract often consume Aloe Vera juice.
Another interesting association from the free radical effect produced from the loss of GSH and SOD from toxic materials exposures is that of nitric oxide production being increased. Rising levels of nitric oxide (NO) in the tissues promote sexual arousal and this is the effect produced by the drug called "Viagra." When the Manhattan Project was begun in the 1940s the plants in Oak Ridge had such a problem with workers having sex on the job that all the plants office and lab area frosted glass were changed to clear glass to cut down on these problems in the work force. The NO effect was particularly strong at the plants that released large amounts of hydrogen fluoride (K-25 and Y-12), that cuts GSH and SOD production via the combination with aluminum forming the AlFx G-protein. There is extensive evidence from the Manhattan Project and from the US Dept. of Energy (DOE) on the problems associated with toxic releases affecting the cellular levels of GSH and SOD leading to illnesses.
Oak Ridge is an interesting place to study the effects of GSH and SOD suppression via occupation chemical exposures, as it has so many toxic materials that fall into this class of enzyme damaging chemicals. Oak Ridge lost some 2 million pounds of mercury from its lithium operations and this affects both workers and a large area into which the mercury escaped. Oak Ridge lost huge amounts of PCBs into area creek and burned PCBs to release dioxin. Oak Ridge and the local TVA power plants released huge amounts of hydrogen fluoride into plant and town areas. All of these pollutants are well known to damage the production of GSH and SOD, and often the workers in specific areas have health problems from the particular workplace chemical toxic of interest. The collective sum of all these chemical agents that damage GSH and SOD is the reason the Oak Ridge area is highly affected by chemical injury problems.
Toxic metal and fluoride releases are connected to the Oak Ridge K-25 gas diffusion plant and a number of workers were noted to be affected by symptoms similar to chronic fatigue syndrome. Gas diffusion plant workers with CFS like symptoms number in the hundreds. The K-25 gaseous diffusion plant lost huge amounts of toxic hydrogen fluoride (HF) to the air of the plant and region and was discovered by questioning workers about processes and releases. Other HF releases from the X-10 "Molten Salt Reactor Experiment" and the Y-12 UF-4 "Salt Shop" operations provided similarly affected workers and correlation to HF toxic effect due to cumulative low level exposures. The large losses of the K-25 plant exposed not only workers, but also downwind residents of the plant to fluorides. Fluorides were highly suspected as area pine trees, which are very vulnerable to fluorides, were showing impact. Fluorides damage the GSH and SOD enzymes of pine trees and acts much like dioxin, which works via this enzyme process to create ROS damage in plants. There was both air / lung pathway effects, soil contamination / food pathways into the gastrointestinal system, and ground and surface water pathways into communities. These pathways for fluorides connected them with the CFS like symptoms and asthma seen in workers and communities. Asthma is directly connected to reduced GSH and SOD. The workers had high levels of calcium that is indicative of fluoride exposure.[66] They also had high retention of metals and high porphyrin. Fluorides tend to be accumulated (integrated) over a lifetime and the same net dose occurs from a ten-unit dose over one year or that of a one unit dose over ten years.
Fluorides cause some of the worst damage to the immune system with very low concentrations. Industrial fluoride emission in Germany in the late 1800s was perhaps the first chemical to produce worker and community health problems. Fluoride is connected to renal stone formation via insoluble calcium fluoride formation, much like what happens with metals in lymph nodes.[67] Veterinarians warn against using fluoride toothpaste on animals and with the knowledge of the lymph node effects fluoride tooth pastes and fluoridated public water become dangerous to public health. Industrial fluoride emission was linked to asthma and to arthritis.[68, 69, 70] Fluoride workers also show their cytokine response biased toward the Th2 in the long term.[71] Fluorides impair the macrophage's at very low concentrations and the effect is strongest in the lymph nodes from the insoluble product effect that is often combined with metals and free radical synergy effects.[72, 73, 74, 75] Fluorides cause swelling of the mitochondria indicating damage to ATP processes.[76] Hydrogen fluoride sets off inflammation in lungs.[77, 78] Fluorides toxic effects set up the same mechanism as seen in the beryllium model. Fluorides are pulled into the lymph nodes and the affinity of fluoride for calcium produces an insoluble precipitate that is similar to the effects caused by the insoluble metals. The effect sets up TNFa and hyper-oxygen damage that locally lowers glutathione in the lymph cells. TNFa promotes viral RNA replication. Increasing viral infection in the type I macrophage's promotes more TNFa and this is multiplied by the repeating effect of cells in the lymph system. This activation of the Th1 process also sets up a switch to Th2 mode slowly as the macrophage's stop working and foreign cell products accumulate in the tissues that trigger the Th2 mode. Th2 suppressor effects on Th1, impaired ATP, glutathione, and other effects contribute to the mode switch.[79] Th2 mode involves IL-10 that further depresses and shuts down the macrophage action and locks in the Th2 mode.
This lymph node / mitochondria impact thesis became a toxic pathway mechanism for immune dysfunction in 1986 that explained the process for all immune linked diseases and even aging / longevity factors. The thesis was that insoluble toxic material, metals and fluoride predominately, accumulated in the lymph nodes and disabled this pathogen destruction mechanism and the toxic presence set up a continuous cytokine response in the lymph system that keeps the immune system triggered and allows pathogen presence.[80] In the early stages of viral activation, a Th1 profile with TNFa is often seen and in a normal immune response these levels control the virus.[81] Internal cell viruses such as EBV, CMV, HHV-6, mycoplasma, cancer viruses, HIV, and etc. can run out of control with a system biased toward Th2. The toxic material concentrations triggered the inflammation effects that cause cell apoptosis, necrosis, consume glutathione, etc. Add in pathogenic components and the outcome is further modified. HIV spends cell energy and promotes TNFa and IL-10, which helps in the demise of T-cells as the disease progresses due principally to the loss of macrophage activity from the IL-10.[82]
The 1991 Gulf War exposed thousands of veterans to various toxic materials that have long retention in the body and set up the same conditions as the toxic metal effects in the lymph nodes. Many of these Gulf War Veterans experience the symptoms of CFS and multiple chemical sensitivity (MCS).[83] Gulf War persons were exposed to HF via hydrolysis of sarin and soman nerve gases, to glutathione depleting insecticides and oil emissions, and to toxic metals from vaccines (Al and Hg) and DU. They also are biased toward the Th2 profiles because of the similarity to the industrial pollution that drives CFS. They were exposed to toxic metals in the form of DU and mercury preservative in Th2 promoting vaccines. They were exposed to halogens in the form of bromine from PB tablets, excessive chlorides from water treatment, various pesticides, and fluorides from nerve gases.[84] Recent studies have shown that those exposed to chemicals have brain damage.[85] CFS affected persons also show brain damage.[86] Gulf War Syndrome (GWS) persons also have fibromyalgia similar to CFS.[87] The pain is driven by loss of sodium channel and ATP in nerve cells, and the calcium rich myelin of nerves is high in fluoride and metal retention that drives this effect. It is not a single chemical factor analysis that solves the illness toxic driven equation, but various toxins acting in the same pathway to disable the lymph system's critical enzymes (GSH, SOD, RNase L) that best explains GWS. This war was the toxic equivalent of hell that dosed many there with 30 years of industrial and environmental pollutants that aged them with health effects to 60 years old females. There is one central etiology mechanism involving chemical damage to GSH and SOD levels leading to increased toxic metals retention in the lymph nodes and cells triggering the cytokine response. The immune dysfunction comes from multiple contaminates acting via a common mechanism that allow varied illness outcomes as determined by exogenous and endogenous viral predisposition's and other opportunistic pathogens.
Food processing and preparation play a strong role in the vitamin and free radical effects in the intestine that affect these cells and their local lymph nodes. Foods processing and cooking destroy most of the nutrients in food. Raw and uncooked living vegetable foods supply more vitamins, as compared to cooked vegetables or fried food.[88, 89, 90] Cooked food has long been associated with delivery of free radicals from foodstuffs to the stomach and intestines and this effect causes some excess production of white blood cells, called digestive leukosis. High temperature fried food supplies the most free radical content and highest toxic exposure due to bio-concentration in the food chain. Raw and uncooked foods don't produce these free radical effects and provide better delivery of enzymes and vitamins, as well as fiber to detoxify the system. Raw food diets aid in mediation of CFS, cancers, and other immune illnesses because of these vitamin and reduced free radical factors. Raw vegetables supply glutathione that helps to keep the metals clearance of tissues and brain working to avoid the build up of toxic metals due to increased biological half-life of the toxic metals from glutathione impairment.
The raw food verses cooked food is also involved with the biblical issues of Genesis. Animal foods add a level of bio-concentration of toxic material from airborne contamination of the animal food chain. Cooking vegetables or animal products produces free radicals from the pollutants and pesticides that can retain more easily in the body. Vegan diets also make the intestine more basic, which results in less immune activation and less absorption of toxic metals. A shift of the blood pH toward acid contributes to higher toxic metals retention because it impairs the rate of metals clearance by the kidney. Because of these effects, the raw uncooked vegan diet is connected toward effective intervention for fibromyalgia, rheumatoid, heart, and cancer.[91, 92, 93, 94, 95, 96] Vegan diets also alter the fecal bacteria levels and bacterial fatty acid generation.[97, 98] The toxic load and nutrient supply in the intestines is highly associated with immune illnesses and long term effects result in leaking gut syndromes. The quick heating pasteurization of milk also produces toxic effect.[99] Raw food diets promote illness recovery. One must acknowledge that most produce in the US is still short of the needed beneficial trace metals that have been depleted by poor farming methods, even in the organic farming realms. Serious persons should shift diets to include sea vegetables to enhance their essential trace metals nutrients.
Raw and uncooked vegetables promote better coupling of the human nutrient absorption systems for uptake of the essential trace metals (selenium, zinc, copper), which help to form the immune repair system with enzymes (GSH, SOD, RNase L) and also helps to remove fluorine from the body and bone mass. Soils in the US have become increasing depleted of these essential trace metals due to acid rain and over-farming without replacement of these metals. Glacial and volcanic effects placed these essential trace elements there, and the effects of industrial acid rains remove or worsen their availability to the food chain. The depletion of these trace metals sets up a rise in the rate of fluorine retention in the bone masses, where the immune system cells are formed. This effect starves the immune system cells formed in the bone mass of the essential metals needed for proper cell DNA repair and resistance against pathogen infections. This effect of fluorine rising in the bone mass is directly connected to the HIV infection process via loss of manganese. The effect also sets up the shrinkage of the thymus gland from these metals depletion effects on the immune cells.
Plant cells and enzymes closely match those in animals and humans, and prove useful in helping return some of the enzyme functions in fluoride affected persons. It sometimes takes 10 years of toxic exposures from materials like fluoride to set up the cellular stress conditions that make for CFS. It also takes around 10 more years to turn around the bone burden of fluoride and get the cellular damage and enzyme processes back up to near normal. The bone retention of fluoride sets up a very long recovery period for those that chose to successfully modify their nutrition and healthy eating habits.
There is more that supports the conclusion that the toxic loading in the lymph nodes shut down the monocytes / macrophage's and is the pivotal problem with HIV.[100] HIV transmission and infections appear most prevalently in the intestine and its local lymph system. Here the toxic load of the food and water chain come into play with cytokine factors and lymph node effect. The intestinal region is the most affected from cooked food free radicals and the uptake of toxics in the food and water chain. Regions in Africa with the highest fluoride in well water and food have the largest problem with HIV transmission.[101, 102, 103, 104, 105, 106] Many of the high fluoride regions follow the east African Rift Valley zone that is lined with volcano and seismic zones. In many of these areas the persons have frosty white teeth from dental fluorosis and many are disabled by age 40. This is significant because fluoride toxic effects set up cytokine profiles that HIV transmission and growth require with TNFa in the lymph nodes and loss of macrophage / monocyte performance driving Th2 bias in the intestines and body as a whole.[107] The TNFa cytokine promotes the viral proliferation of HIV.[108]
The rise of fluorides in the body is the principle trigger for HIV infections due to the fluoride in the bone mass upsetting the beneficial trace metal concentrations for cellular enzymes. HIV affects the 2-5A RNase L enzyme pathway in cells, so the fatigue associated with CFS is altered when HIV enters the equation. Fluoride in the bone mass robs the immune cells that form there of the essential metal manganese that is needed to block reverse transcripion of HIV in cells.[109] This effect sets up the high rates of infectivity in the lymph systems immune cells by HIV, with the virus setting up the higher rates of TNFa that promote rapid growth. HIV is highly sequestered in the lymph nodes of the gut region, where the highest exposure due to fluorides and metals affects the lymph nodes and bone mass. The high level of mtDNA damage from metals promotes excessive NO production and damage factors.
HIV, as it infects more cells in the body, sets up its own cytokine signatures that become the additional factors on top of the toxic effects that keep it from being regulated. HIV also produces IL-10, which suppresses macrophage action.[110] Impaired monocyte / macrophage function is highly associated to HIV progression and pathology for other viral infection.[111] Rising IL-10 levels that suppress macrophage action directly connect to the loss of CD-4+ T cells.[112] These T-cells are preferentially attacked due to the gp120 bonding site on T-cells that promotes HIV cellular transmission into these cells. The early AZT treatment acted more to destroy cell mitochondria than to oppose HIV replication.[113, 114] HIV always involves activation of other viruses and these can worsen the cytokine activation and AIDS progressions.[115] HHV-7 is often activated in HIV infected persons and the lymph nodes are seen to be the site of reactivation.[116] This leaves little doubt that the failing lymph node effects play a central role in HIV proliferation. This can also be seen in the case of cancer viruses where the failing lymph node cellular regulation allows cancer metastasis of lymph nodes and helps to spread the cancer viral infection. The same effect also spreads HIV and other viruses, rather than regulate and destroy them. The HAART treatment for HIV lowers the AZT dose and avoids using TNFa mechanisms that promotes HIV transcription and this has almost rendered HIV a chronic survivable disease, with many having near normal life-span with non-detectable HIV in their blood. The principle problem with HIV and the immune system is that TNFa triggers it and loss of manganese sustains its replication. The key factor is macrophage and monocyte enzyme performance for regulation of HIV, with the exposure to fluorides dominating this performance in many countries.
The dominate effects of the fluorine atom's affinity toward metals in the body is easily established via the fluorine deposition rates in the bone mass and other calcium rich tissues. Fluoride absorbs into the calcium phosphate or hydroxyapatite of the bone mass, as well as the hydroxyapatite in the pineal gland, where the serotonin / melatonin hormone process is antagonistically affected.
Fluorides rise in the bone mass contributes to the depletion of selenium needed for making the enzyme Se-glutathione and the copper and zinc needed to produce Cu-Zn superoxide dismutases or SOD. [117, 118, 119] Fluoride antagonism toward selenium also upsets the thyroid autoimmune hormone process. [120, 121] The depletion of these enzymes contributes toward the retention of toxic metals (Hg, Cd, Al) from acid rain effects on soil and food chain uptake. The retention of these toxic metals damages the cellular mtDNA and ATP production levels of cells due to the mutated enzyme RNase L. Fluoride's affinity toward beneficial trace metals damages literally 100s of enzyme processes that lead eventually toward poor health, illness, and death.
GSH or Se-glutathione supplies a sulfur atom for toxic metals to bind that renders to them the same solubility factors as were dominate when the Earth's metals were formed from volcanic dominated sulfur releases. The effects of HCl dominated Acid Rain are upsetting the soils metals speciation and increasing the levels of metals availability from the change from the sulfur domination. This results in damage to the Cu-Zn SOD as metallic elements like manganese compete against the copper-zinc. The combination of rising fluoride and acid rain set up loss of GSH and change of metals speciation for the SOD that sets up the problems leading to prion and mad cow problems. Chemicals like DMSO that supply sulfur atoms to bind metals deep into tissues and the brain have been shown to reverse the manganese amyloid plaques associated with prion diseases.
The UV and Ozone Hole problem has severely upset the global sulfur cycle upon which the Se-GSH system depends for adequate sulfur. The ocean plankton levels have been reduced which causes an increase in the global CO-2 levels and a loss of DMS that is formed from the process that regulates cloud formation. The loss of cloud seeding by the DMS causes the bulk of the global warming problem via loss of reflective clouds for the IR radiation reflection. Plankton are the world's largest CO-2 sink and the largest system that places sulfur into the human and animal food chain. When the DMS is impacted by UV radiation, it lowers the DMS, DMSO, and MSM pathway into the human chain to supply the levels of sulfur needed by GSH in the liver and cells to remove toxic metals from the body. This systemic loss of sulfur stores causes a metabolic acidosis and hyperthyroid shift in the population that results in CFS and many other immune illnesses.
Mad Cow or BSE is characterized by plaques with high levels of manganese. The mitichondria when under toxic stress makes Mn-SOD, that is the reason for these plaques and tangles in the brain. The high levels of toxic metals in the brain due to loss of GSH stimulates the increased Mn-SOD variant. The mitochondrial processes taking up all the cellular manganese depletes that needed to make the enzymes to protect the cell from internal viral activation. Viral protective enzymes like 2-5A RNase L require manganese to do their job as does interferon that protects cells from viral infection.
The fluoride damage to the enzyme processes like Se-glutathione (GSH) and others like it set up factors that result in retention of the toxic metals such as mercury, cadmium, lead, nickel, and others. [122] This results in the appearance of persons with high fluorine effects having heavy metal poisoning. The fluoride effect driving the retention of metals like mercury add dramatically toward the nervous system damage and loss of T-cells. The loss of GSH and other clearing enzymes results in a see-saw like effect where the beneficial trace elements such as selenium, zinc, magnesium, and copper are depleted and the harmful metals like mercury, lead, cadmium are increased. [123, 124, 125] Such observations often lead to chelation type therapy, which needs to be done carefully with reintroduction of beneficial mineral cocktails and keeping GSH levels preserved or increasing. This type effect is readily seen in the DOE K-25 gas diffusion plant workers exposed to HF associated with Oak Ridge, Tennessee.
Hydrogen Fluoride (and other fluoride compounds) taken into the body will spontaneously form aluminum compounds that are similar to the pesticide called cryolite. Cryolite insecticide works by upsetting the trace metals metabolism within cells. Every man, woman, and child on this planet is being affected by this chemical insecticide forming inside the bodies and damaging their metals metabolism and in the long term. It is a dominant effect that results in death by a process like the novel called "Arsenic and Old Lace." Placing a safer metal into the blood circulation by adding titanium dioxide to the food chain is being used to offset this formation of the Al-F compound effect on human and animal health.
The reduction of GSH for removing toxic metals via the bile pathway shifts toxic metals into the kidneys and slows the clearance of all toxic metals due to the pH effects on clearance of metals by kidney cells, which promotes blood pH shifts toward metabolic acidosis. Kidney damage and heart damage go hand in hand because of this relationship with build up of toxic metals within the body due to loss of GSH levels. Heart disease and kidney disease always go hand in hand, as high blood pressure from arterial disease causes renal failure. The cholesterol build up on arteries is directly associated with toxic metals / fluorides adhering to the arterial walls and the cholesterol repair mechanism attempting to repair the problems. These are processes that are the normal outcome of old age, but the onset of these old age factors is a direct function of the GSH impairment from both natural and industrial exposures. Cancers and the neurological outcomes are the outcome of the same process of loss of GSH and SOD with age due to environmental accumulation.
Heart disease yields an interesting association with salt, because doctors recommend to stop to control blood pressure. The problem with table salt is that it has aluminum silicate added to keep it flowing. The blood has a high concentration of salt on the order of seawater concentration, so dietary salt is not going to be what causes the high blood pressure reaction. Aluminum will combine with fluoride in the blood making the AlFx compound that lowers GSH and provokes the build up of metals in heart cell mitochondria and high rates of ROS production. The administration of nitro-glycerin for heart pain promotes the production of SOD in the heart cells and the neutralization of the ROS within the cells. A very similar effect happens in the brain with metals accumulation that causes increased ROS and the metal lithium being used to trigger increased SOD to counter mental disorders. Ending the use of salt with aluminum hydroxide acts to lower the kidney stress factors from toxic metals accumulation and lowers blood pressure. This effect is very telling of the sensitivity of the body to aluminum / fluoride affecting GSH levels.
The aluminum in salt and aluminum in baking power observations began to break the secrets of CFS in the 1980s at ORNL. CFS and GWI symptoms like "night sweats" are easily explained once one finds that the AlFx G-protein effect mimics the TSH hormone generated by the pituitary gland. When the AlFx levels formed from the foods a person consumed during the day exceed the levels of TSH hormone from the pituitary then the cells can't power down at night from the dynamic control of the mitochondria by the pituitary TSH and thyroid process. Likewise, other symptoms like inability to sleep or get rested sleep could be explained. What they were experiencing was the effect of hyperthyroidism, which involves extreme tiredness, inability to sleep, and loss of GSH. It is this running full power 24 hours a day that exhausts the supply of GSH in cells. The body intentionally powers down at night to replenish GSH and do cell repair processes and this cannot happen when TSH mimic compounds like AlFx take control over thyroid hormone levels.
The characteristics of the AlFx compound in the mimic of TSH is a very destructive method, as the fluorine component of the compound causes a bond that does not clear as does the normal TSH. The highly electronegative effects of fluorine causes the AlFx to bond long term to receptor sites of cells. This process highly upsets the normal pulse and amplitude processes of the pituitary control via TSH on the thyroid hormone generation. The characteristics of the AlFx compounds to form almost permanent bonds to the receptor sites for TSH highly damages the cellular repair processes and GSH levels within cells. The heart of the problems with the AlFx compound is that it doesn't follow day and night variation of normal TSH and the fluorine component of AlFx forms a nearly permanent bond to TSH receptor sites, which causes severe thyroid hormone regulation problems. This is why the AlFx compounds play a dominant role in cellular GSH depletion throughout the body and human health.
One of the problems in detection and diagnosis of this effect is that doctors will only run simple TSH tests for thyroid function, which will often show up as low when the AlFx compounds are driving the over production of thyroid hormones. When the doctor sees a low TSH he declares the person as having hypothyroidism, when just the direct opposite is the case. The doctors need to run the "Total Thyroid Panel" type test to get a better idea of what is happening with T-3 and T-4 and see if things like AlFx and other thyroid affecting chemicals are causing problems. This is part and parcel for how the AMA doctors avoid exposing the industry that poison people via this process.
The American population has been poisoning itself with this low level of aluminum and fluoride in the food chain. The incidence of common colds, flu, and fever are strongly correlated with high much flour and salt with aluminum content enters their diets. The duration of colds, flu, and fever was correlated with diet and the time of clearance of these materials from the gut. This effect was similar to the night sweat effects seen in CFS and GWS, which stemmed from the highly abnormal thyroid hormone mimic effect of AlFx compounds. It was found that fever and sudden recovery would trace the elimination of these food materials from the gut. It was also found that persons that consumed too much aluminum in flour and salt exhibited higher rates of heart problems. They exhibited early brown spots on their skin similar to liver spots that warn of liver damage, and they had degenerative mental problems that resembled ADD and dyslexia. It became clear there were ways to avoid colds and flu, and that Americans have been poisoning themselves chronically from the rising Al and F effect in their food chain.
Environmental legislation has slowed some of the toxic effects from the chemicals that damage GSH and SOD enzyme levels. The Government has not been clear as to why DDT, PCB, Dioxin, and varied chemicals have been banned, but the major reason has been to slow down the toxins that damage GSH and SOD enzymes. It is a case of not enough or soon enough, as the problems continue to mount. Eating fish has been suggested to be limited to once a week over the same problems with mercury. The current trend is that industry is being protected, while the citizens have been increasing affected. The systemic health problems due to these many chemicals and damage GSH and SOD enzymes show up clearly in areas like Oak Ridge and the HF toxic releases and Al vaccine problems from the Gulf War.
The analysis of the trace metals factors leads again to the metals speciation shifts due to fluorine's presence in the body and bone marrow. Here the issues of the Old World belief in the trace metal copper being linked to eternal life come into play. Copper is grouped with silver and gold in the valence column of the Periodic Table. Examination of the elemental gold reveals that in its Gold +0 metallic state that it very non-reactive with most ions, with exceptions being mercury via the amalgam effect and fluorine due to the high electronegative effect. Gold colloid particles would become a sort of "teflon bullet" and be able to migrate past brain and cellular membranes and become effective in the removal of mercury from the tissues and brain, as well as aid in the removal of fluorine itself. This concept stems from ancient alchemical texts and the science arts from Egypt and plays a strong role in early religious beliefs and practices leading toward higher brain functioning and longevity. Similar concepts called "acupuncture" for pain therapy using metallic needles of copper, silver, and gold inserted into tissues are associated with the same fluorine and mercury removal concept. These concepts are applicable toward treatment for CFS and other fluorine induced illnesses.
It is these factors that set the stage for the appearance of CFS in volcanic zones like the Lake Tahoe region, as found by Cheney. The loss of ATP, the depletion of GSH, and the appearance of multiple endogenous viruses in the body are the direct result of the synergistic effects of rising fluorides on the beneficial trace metals needed for the proper functioning of the human immune system. Fluorides in the body cause the loss of the beneficial trace metals required for proper enzyme protection of cells, and the rise of the toxic metals that damage mtDNA and ATP production. The effects set up increased rates of cellular damage from NO and other oxidation effects (ROS). The net result is called Chronic Fatigue Syndrome. The mechanism is common too not only CFS, but to HIV infectivity and the process leading to cancers. Fluoride causes acidosis of the body and with this comes even greater loss of ability to clear toxic metals by the kidneys and the high levels of metals damage that set up cancer by loss of immune system regulation.
This analysis process leads to a new more inclusive model for total oxidative stress for cells that involves radiation induced oxidative stress directly, chemicals that alter thyroid hormones and lower GSH and SOD, and exposures to toxic metals that set up high rates of mitochondria malfunction and production of ROS. The total oxidative stress model for cells predicts that the AlFx and mercury interaction as thyroid hormones and the GSH and SOD depletion with age dominated pre-industry health effects. The postindustrial effects must include the PCBs, DDT, Dioxin, Hg, and others that similarly alter thyroid response and reduce the GSH and SOD protective enzymes. When the "Total Oxidative Stress Model" is used, which includes the loss of GSH and SOD and its clearance mechanism for toxic metals in the body, then the biological sciences correctly models the cellular protective enzyme health mechanism. This process then accurately models the failure mechanisms for CFS, Cancer, AIDS, MS, BSE / mad cow, Scrapie, Alzheimer's, Kidney / Heart Disease, and etc.
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The author formed and directs the Magnum-Opus Project to correct and expose the wrongs the Manhattan Project and the abuses of openness in national security. He is former Senior Development Staff of Oak Ridge National Laboratory and has direct experience with some of the most toxic materials from the nuclear industry. He worked on toxic site remediation, radiation detection, invented the USRADS survey system, and won ORNL significant event award. He discovered high levels of hydrogen fluoride emissions from the gas diffusion plants and noticed the link to CFS like illnesses in the worker and local community populations. He defined the basic mechanism for cancer, CFS, and HIV in national security circles in the 1980's. He claims his inspiration for the discovery came from the icon imagery of volcanism connected to the story of the Ark and the environmental imagery associated with Mary controlling the poisons from the Earth entering the food chain. The ultimate of the inspiration came from the understanding of the Global Sulfur Cycle and how this associated to the story of a volcanic mountain near an oil field of Midian, Saudi Arabia and how this process formed DMS. Author says enzyme, bone, and lymph immune system mechanism information was suppressed for more than two decades by industry control of research, negligence on the part of CDC, ATSDR, and EPA, and criminal cover up on the part of the DOE. He purposely chose public publication of his work to express the need for preventive and alternative medicine to take a more balanced stance against AMA and pharmaceutical based dominance and excessive profiteering in medicine.
The aftermath for the Manhattan Project is the fitting setting for the discovery of the principle failure mechanism leading to cancer, CFS, immune illnesses, and AIDS. The Manhattan Project discovered early on the acute effects of radiation due to ROS forming in the marrow death, intestinal death, and nervous system death effects. The studies in Oak Ridge also found that sub-lethal radiation exposures lead to the need for antibiotics to protect the person from the immune system loosing its ability to protect against viruses, mycoplasma, and other infections.
The 1980s brought on the problems of AIDS and HIV nearly simultaneously, and the research in this period identified the loss of glutatione (GSH) and superoxide dimutase (SOD) enzymes connected with CFS. The glutathione metals clearance mechanism also pinned down that toxic metals upset the cell mitochondria processes leading to high rates of ROS from the mitochondria ATP production. CFS would involve endogenous DNA viruses, HIV exogenous retrovirus from monkeys, and cancer the radiation mutation of activated endogenous viruses. The entire process for CFS, AIDS, and cancer was uniquely defined by three simple enzymes: Se-GSH, Mn-SOD, and Mn dependent 2-5A RNase L.
In the 1980s, Jim Phelps was the first at Oak Ridge to correctly flag all the problems of the Ozone Hole or the UV problem in upsetting both the Global Warming factors and the Global Sulfur Cycle of the planet. The largest CO-2 sink on the planet is the ocean's plankton and the UV was impairing and killing the plankton's CO-2 conversion process. The plankton process is also part of the global Sulfur Cycle that supplies DMS into the atmosphere that places DMSO and MSM into the human and animal food chain. These place sulfur into the food, which is in turn used to make the Se-GSH to clean the body of toxic metals. DMS also supports cloud seeding that acts as a sunscreen for heat from the sun and regulates the Earth's temperature. The loss of DMS levels directly drives global warming and the loss of immunity in humans and animals.
The higher levels of retained metals in the body due to loss of the hepatic phase II elimination of toxic metals sets up a slow shift toward hyperthyroidism like problems due to the AlFx effects and this process sets up a metabolic acidosis that slows the kidney clearance of aluminum and other metals. The rise of the toxic metals within cells causes mitochondria ROS generation to rise and greater demand on Mn-SOD to compensate, and upsets of the Mn dependent 2-5A RNase L generation.
With the discovery of the function of the 2-5A RNase L enzyme in controlling the internal cell viral infections the association of the metals induced ROS and the radiation induced ROS paths crossing paths became highly evident. The discovery that these three enzymes dominated the failings of the immune system from either radiation or toxic metals was fully discovered in the mid-1980s at Oak Ridge National Laboratory by Jim Phelps.
Jim Phelps' discovery of this principle mechanism for illnesses began when his father became sick while working as a uranium machinist at the Y-12 plant and was highly exposed to PCBs used as a uranium cutting tool coolant. This lead to gall bladder problems, which are directly connected with PCB exposures. The Y-12 managers moved Jim Phelps father from the dirty PCB uranium cutting operations to the cleaner Y-12 9201-1 buildings operation.
Jim Phelps' Division at ORNL designed the TSCA incinerator for the K-25 plant in the 1980s and he discovered the issues behind the need to ban PCBs and Dioxin were due to cumulative damage effects to the enzymes GSH and SOD, which eventually leads to free radical damage to the RNase L enzyme's effectiveness and viral infection problems within cells. Jim Phelps' dad came down with Parkinson's and had to take early retirement from Y-12, and the mechanism of glutathione was the main clearance mechanism for toxic metals and chemicals from the brain. Jim Phelps quickly spotted this as associated with his father's progressive illness pattern from his occupation exposures at Y-12.
Jim Phelps' dad also worked on the K-25 improvement program which exposed him to aluminum parts run in a fluoride chemical process, which made an extremely dangerous AlF3 coat on these parts. This exposed his father to one of the most dangerous of the Oak Ridge toxic insecticide effects that mimic the TSH pituitary hormone and upsets the GSH and SOD levels in cells. His dad had multiple toxic insults [PCBs, then AlFx] to the same enzyme systems that protect the body and brain from toxic injury. This was the process that cracked the issue that Harold Hodge spotted in 1944 about the F factor causing health problems in those exposed to UF-6. The AlFx problems were now exposed, and the process via which they caused illnesses in the work force.
With that mechanism defined, it was a short time before the problems of hydrogen fluoride (HF) and other toxins were identified as upsetting the GSH and SOD levels. HF effects were quickly connected to the high rates of thyroid illness seen in the work force due to accumulation of mercury in the thyroid gland leading to thyroid cancer like problems normally associated with radiation damage.
These were the natural order of events that lead to the major discovery for the causes of cancers, CFS, immune disorders, and even AIDS in the mid-1980s at the Oak Ridge National Laboratory by Jim Phelps.
Jim Phelps was the first to connect that HF emissions from the Oak Ridge plants impacted GSH and SOD, and that this effect was becoming worse on a national scale from coal plant emissions of HF. The effect was leading to problems of "Mad Cow" and "BSE" in even grazing animals. Jim Phelps proposed the mediation factor by spraying titanium dioxide from planes to offset the problem in grazing animals.
This idea became the start of the so called "Chemtrails" activities and top secret compartmented research at LANL on the rising problem in animals. Jim Phelps also discovered an atmospheric injection vector involving HF and H2SO4 in combination with hydrocarbons in the air that dominated the global warming effects.
Jim Phelps discovery that all of medicine comes down to damage factors from environment and industry to these three principle enzymes proved highly embarrassing to the Govt., Industry, and AMA; to the point that the AMA styled medicine could be forced out of business and charged with malpractice on a national scale. This began the massive cover up for this discovery that could well change the world, if it became public knowledge. Jim Phelps' discovery not only showed that the common cold could be made extinct, but that man could be made to have the Biblical longevity of Genesis. His discovery even impacted the interpretations for religion and exposed massive problems there.
The discovery of the toxic metals mechanism has strong links to religion, as the Egyptians were into metals mining. They were the first to use copper for water pipes, while the Romans used lead pipes and poisoned themselves into self-destruction. Also in these times, Joseph of Aramea held tin mines in the UK, and the so-called "white lead" made a highly safe metal for use in cookware and food storage. "Tin lined" copper cookware (Gérard Leclerc, etc.) is still in use today and is some of the finest and most expensive of French cookware.
In these old world cultures the use of mercury, which is the worst of the worst of toxic metals, in the mining for gold via an amalgamation process made Kings and Rulers rich. It was not in the interest of the powers of those times to expose that mercury made these gold miners sick, so that information was suppressed. Vatican and Jewish religious interpretations of issues like eternal life were suppressed in those times as they played the game that kept them and their rulers in gold.
The US plays the same games today in the cover ups on health connected with processing aluminum, a strategic metal. Aluminum uses fluoride to process it to metal and the AlFx health effect on GSH and SOD appears there strongly. Similarly the strategic metal Uranium production for bombs uses lots of Fluorine and coal power that released mercury and HF. This too causes serious AlFx health problems. And the list goes on into the cover-ups on PCBs, Dioxin, DDT, and all the other chemicals that suppress the GSH and SOD enzymes needed for health and longevity.
The knowledge of the GSH, SOD, and Mn based viral protection enzymes is literally the issue of how to attain very long longevity by avoidance of toxic metals and chemicals. This is the theme of the eternal life part of religion and elements from the story of Genesis. Moses was educated in Egypt by what some term the Egyptian School of Mysteries or what might better be termed the school of the natural orders of the world. They knew well the power of metals to heal and to make ill. There was one special metal that had the ultimate power to heal and produce clarity of mind, expanded cognitive powers, the realm of divine thought. Gold Colloids were part of the story of Moses and the Manna. Later, Jesus and Joseph lived in Egypt and were exposed to these same teachings.
Jesus was termed a magician and had unusual powers to heal people. In those times the knowledge of natural processes and the health problems linked to fluoride and toxic metals effects would be the ultimate in health knowledge. This knowledge is still the ultimate in health conservation today. It is this knowledge that appears connected to the graduated learning needed to attain that associated with the Holy Grail.
The Masons Organization (Scottish Rite Temple) still practice part of this ancient Egyptian School of Mysteries type teachings in their progressing up their orders. They seek to imitate the knowledge and attainments from Old Egypt that lead to Jesus' divine level of knowledge.
So, one can now see that the information of how health is affected by toxic metals can play a strong role in the interpretations and misinterpretations of the church on the true story of what Jesus was about. Jesus was also said to be an Essene and this faction also practices a version of the divine knowledge keeping from the Egyptian Mystery School knowledge base.
It is for this association that many of these illnesses connected with this failure mechanism are called "mystery illnesses;" CFS, GWS, Gas Diffusion Worker Illness, Cancer, ALS, etc. The illnesses represent no mystery, as the mechanism for them is well known. To acknowledge the mechanism for these illnesses is to open up Pandora's Box and to expose the very serious problems in religion, both in Judaism and Catholicism, as well as the problems of modern medicine that make their entire profits from this health failure mechanism.
One of the most prized metals in Egypt was copper and was associated with eternal life and the symbolism of the Ankh (The first religious Cross). Later, gold took over as the leading metal for health, as its colloid form could remove fluoride and mercury from the body and brain. The ultimate powers of the Ark of Moses were closely associated with this metal's healing power and how to make it.
Thus, one can see why the corrupted power of religion and government in the US attempt to keep these associations a mystery for the public at large. Keeping the mechanism a mystery allows industry to pollute and harm health of large populations, while others make money from treatment of the illnesses induced. Doing such is a crime against humanity and racketeering beyond the wildest imagination. Those associated with such deception are assigned the definition of anti-Christ.
It is these three enzymes that form a sort of Holy Trinity for man's existence on this planet, and the inner sanctum for why Jesus was so special in the realm of religion. With the knowledge of the Final Diagnosis report in hand, the real issues of religion come into view. It is part of the story of Jesus' Revelations.
The bottom line is that places like Oak Ridge released hydrogen fluoride, which combines with aluminum in the body to form a toxic compound like the insect poison called cryolite, sodium aluminum fluoride. Cryolite's pesticide mechanism works by upsetting the trace metals metabolisms within cells, and this is exactly the problem seen in Oak Ridge and elsewhere with the mysterious illnesses and diseases. It affects every man, woman, and child on this planet and is directly connected with killing them in the long term.
This same effect is the trigger mechanism for Gulf War Syndrome, and all that and much more could have been averted if Oak Ridge was not a criminal entity seeking to cover ups its many mistakes and toll on human life.